Links are to Wikipedia:
Some important sights in Midtown:
- Empire State Building
- Museum of Modern Art
- St. Patrick's Cathedral
- Grand Central Terminal
- New York Public Library
- Chrysler Building
- Time Warner Center
- One Bryant Park
- United Nations Headquarters
- Carnegie Hall
- Madison Square Garden
- Manhattan Center
- James Farley Post Office
- Pennsylvania Station
- Plaza Hotel
- The Waldorf-Astoria Hotel
- Bryant Park
- Trump Tower
- Times Square
Some shopping: flagship stores of retailers such as:
- Bergdorf Goodman
- Lord & Taylor
- Saks Fifth Avenue
- Bloomingdale's
- Brooks Brothers
- F.A.O. Schwarz
- J. Press
- Macy's
- Nat Sherman
- Paul Stuart
- Tiffany & Co.
As for hotels, this is a very personal choice, so this is a link to a Google search for "Midtown Manhattan Hotels"also www.nyc.com has a great database.
Shopping: Great link to Must See NY Shopping page here
Restaurants: Awesome site here you can search by neighborhood, cuisine, prices. Really cool!!